The Louisiana Department of Health/Office of Public Health is collaborating with federal, state, and local law enforcement agencies, first responders, 9-1-1 call centers, and the Department of Corrections to expand the Louisiana Opioid Data and Surveillance System to include nonhealth data sources, which will be built by third-party contractor GCR, Inc. Louisiana also will conduct post-legislative and post-policy impact analyses and support data-driven methods for cross-system and interagency planning and collaboration. The goals are to enhance surveillance of the opioid abuse continuum to include analysis of offenders, administration of overdose reversal drugs, and drug seizure information. Data linking with the state’s prescription drug monitoring program, a current partner, is planned. Louisiana also will engage a stakeholder group to develop best practices for data-sharing efforts and is planning the creation of an opioid death review panel. Louisiana is supporting other COAP grantees statewide.