The St. Louis County Prescription Drug Monitoring Program (PDMP) is the first locally based PDMP in the country. The St. Louis County Department of Public Health (DPH) serves as the program administrator, and any Missouri jurisdiction may subscribe to the St. Louis County PDMP upon enacting authorizing legislation and signing a user agreement with St. Louis County. Fifty-eight jurisdictions are currently participating in the PDMP, including 79 percent of the Missouri population and 92 percent of health care providers. The project supports expansion and increased use of the PDMP. Project goals include delivering technical assistance and support to promote engagement and use of PDMP information; educating and recruiting additional subscribers to improve the value and utility of the PDMP database; and designing and refining utilization data and reports. A grant-funded biostatistician will be hired to establish the data infrastructure for generating reports and data analysis made possible by the PDMP. A PDMP technical advisory committee will meet quarterly throughout the project period.